The Glucose transporter 1 (GLUT1) is a protein in humans encoded by the SLC2A1 gene. GLUT1 facilitates the transport of glucose across the plasma membranes of mammalian cells. GLUT1 is responsible for the low-level of basal glucose uptake required to sustain respiration in all cells. A high expression of GLUT1 immunoreactivity in cancer (esophagus, stomach, colon, lung and breast) has been associated with aggressive behavior and shorter survival.
This APP can be used for quantification of GLUT1 membrane immunoreactivity. The parameters used in the APP allow measurement of the expression of sodium/proton exchangers at the plasma membrane in tissue sections. As the function of sodium/proton exchangers relates to their localization, quantitative assessment of localized expression will presumably correlate with function. Comparison of matched sets of samples (e.g. tumors versus normal) allows correlation of expression as a function of (disease) status.