The annexin family is composed of 12 eukaryotic members participating in diverse important biological and physiological processes including anti-coagulation, endocytosis, exocytosis, immune suppression, differentiation, and tissue growth see, [1][2][3][4]. Many studies have shown the annexins to be among the genes consistently differentially expressed in neoplasia. Increasing evidence also indicates that cancer-specific changes in annexin expression or in their subcellular localization contributes to development and progression of cancer by affecting cell signaling pathways, cell motility, tumor invasion and metastasis, angiogenesis, apoptosis, and drug resistance, see [4][5]. Furthermore, Annexin 10 has been reported to be correlated with poor prognosis in hepatocellular carcinoma [6], gastric carcinoma [7], and latest in urothelial carcinoma, see [8].
This APP can be used for quantifying the nuclear expression of Annexin 10. The approach to calculating expression used here, was demonstrated to have a high correlation to manual scoring in a study involving 300 patients (R2 = 0.70) (publication pending).