Sjögren’s syndrome is an autoimmune disease characterized by infiltration of lymphocytes in the striated ducts of salivary gland tissue. The most common symptoms of the syndrome are dry mouth and dry eyes resulting from decreased production of saliva and tears.
Evaluation of the lymphocytic infiltration is relevant in the study of the pathogenesis and outcome of Sjögren’s syndrome, see [1] and [2]. A manual evaluation of the infiltration is challenging, especially if it should be limited to the striated ducts of salivary gland tissue. This APP allows for automatic quantification of CD3 positive T-cells and CD20 positive B-cells within CK positive ducts.