Uterine natural killer (uNK) cells in the pre-pregnancy endometrium have been associated with recurrent miscarriage. Immunohistochemical (IHC) analysis of endometrial tissue sections has demonstrated increased density of CD56+ CD16- uNK cells in the mid-luteal phase endometrium in women suffering from idiopathic recurrent miscarriage and recurrent implantation failure compared to fertile controls, see [1].
This APP measures the ratio of uNK cells among the stromal cells near the epithelial edge. Cells in the glands and in the epithelial edge itself do not contribute to the calculations.
This APP is designed to work on approx. 3 µm sections of endometrial tissue immunostained with anti-CD56 monoclonal antibody and counterstained with Mayer’s haematoxylin.
CD56, Endometrial Tissue
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