CD74, also called invariant chain, plays a role in MHC class II antigen presentation for immune response. Its expression in tumor cells has a prognostic value as well as immune response signaling in many tumors. Thus, it has a potential role in the regulation of an anti-tumor immune response, and has also been shown to be expressed in inflammatory disorders and other inflammation-associated cancers.
The “10130 – CD74, Melanoma, TME” APP detects nuclei and classifies them as either negative, 1+, 2+ or 3+ based on the CD74 staining expression present in each nucleus’ vicinity.