The endocrine pancreas has a significant remodeling capacity and plasticity that plays an essential role in the maintenance of glucose homeostasis. It is now well accepted that beta-cell mass is dynamic and adjusts to meet the changes in metabolic demand, both in physiological and in pathological conditions. Despite an increased focus on the beta cell dynamics in pharmacological settings, the application of reliable techniques is still needed. Stereological methods have been developed and tested but are usually hampered by the low efficiency in terms of time. The combination of new digital platforms, image analysis software and new stereological sampling techniques are believed to revolutionize the quantitative assessment of beta cell dynamics. This APP calculates the Beta cell and Non-beta cell areas, and the results have been validated using stereological point counting methods.
Mouse, Diabetes, Beta- & Non-beta Cell Area
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