NT (nitrotyrosine) is generated on the tyrosine residues in the specific proteins, which represents a marker of oxidative stress associated with protein dysfunction. Increased nitrotyrosine expression in tumor cells predicts poor outcome of the disease. Immunohistochemical detection of increased levels of protein-associated nitrotyrosine is widely used as a surrogate marker of in situ inflammation.The “10135 – NT, Melanoma, TME” APP detects nuclei and classifies them as either negative, 1+, 2+ or 3+ based on the NT staining expression present in each nucleus’ vicinity.
NT, Melanoma, TME
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