DEVELOPED TO SUPPORT THE STAGING OF FIBROSIS FOR NAFLD AND NASH USING PSR IN RODENTS
In the development of medical knowledge within non-alcoholic fatty liver disease (NAFLD) and the more progressive form non-alcoholic steatohepatitis (NASH), it has been identified that biopsy evaluation is important for NAFLD treatment [1]. The condition is confirmed using the histopathological NAFLD Activity Score (NAS), which grades the severity of steatosis, hepatocellular ballooning degeneration, and inflammation. In addition, fibrosis is evaluated using a separate validated staging system. However, histopathological disease scoring systems are subjective and prone to inter- and intra-observer variation [2]. This Animal Research APP uses a deep learning-based strategy to obtain an accurate and objective method for scoring fibrosis in mouse models of NAFLD and NASH
This APP implements the Brunt fibrosis staging system [3] adapted for mouse models using a Picrosirius Red (PSR) stained section6. The work of this APP has been published as an abstract and as a poster on 17th European Congress of Toxicologic Pathology (ESTP 2019) and at the American Association for the Study of Liver Diseases 2019 (AASLD) [4].
For research use only. Not for use in diagnostic procedures.