Tripartite motif-containing 29 (TRIM29) is a member of the TRIM protein family. TRIM29 expression has been shown to increase cell proliferation through the inhibition of p53 activity. TRIM29 binds p53, resulting in its export out of the nucleus, and this interaction is fine-tuned by post-translational acetylation of TRIM29, see [1]. It has been suggested that TRIM29 is involved in the response to DNA damage through its regulation of p53 and that it could potentially function as an oncogene that promotes tumor growth, see [2]. Immunohistochemical analysis has showed that the expression of TRIM29 is increased in most invasive pancreatic cancers and is correlated with high expression levels of β catenin, see [3]. A clinical study in gastric cancer has also shown that TRIM29 expression correlates with poor histological grade, large tumor size, extensive tumor invasion and lymph node metastasis, see [4]. Recently, TRIM29 has been shown to function as a tumor suppressor in breast cancer, see [5].
This APP can be used for quantifying the cytoplasmic expression of TRIM 29. A very high correlation to manual scoring, in a study involving 300 patients (R2 = 0.78), was demonstrated (publication pending).