Nasal mucous cell metaplasia (MCM) is a remodeling process where nasal respiratory epithelial cells undergo metaplasia to mucous cells. This causes an increased production of mucous, which leads to increased airway obstruction. Mucous cell metaplasia is often observed as a feature of allergic airways disease after exposure to an allergen. The mucosubstances in the respiratory epithelium are identified by staining with Alcian Blue (pH 2.5)/Periodic Acid-Schiff (AB/PAS or AB-PAS). Using this APP the degree of mucous cell metaplasia is quantified in the nasal respiratory epithelium as the volume of mucosubstances per length of basal lamina.
Rodent, Nasal MCM, AB-PAS
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