Pulmonary mucous cell metaplasia (MCM) is a remodeling process where bronchial epithelial cells undergo metaplasia to mucous cells. This causes an increased production of mucous, which leads to increased airway obstruction. Mucous cell metaplasia is often observed as a feature of allergic airways disease (e.g. asthma) after exposure to an allergen (e.g. house dust mites). The mucosubstances in the epithelium are identified by staining with Alcian Blue (pH 2.5)/Periodic Acid-Schiff (AB/PAS or AB-PAS). Using this APP the degree of mucous cell metaplasia is quantified in pulmonary bronchioles as the volume of mucosubstances per length of basal lamina.
Rodent, Pulmonary MCM, AB-PAS
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