Phosphohistone H3 (PHH3) is a mitotic marker and has prognostic capabilities when applied to breast cancer tissue. The mitotic index can be obtained by PHH3-immunohistochemical staining, which can be used as a supplement for diagnosis. CK5 is overexpressed in tumors located in the oral cavity, oropharyngeal, hypopharyngeal and laryngeal areas [1] and can, thus, be used as a tumor marker.
The “10097 – PHH3 + CK5 VDS, Neck Cancer” APP automatically detects and quantifies PHH3 positive nuclei within tumor regions that are identified based on the PHH3 and CK5 virtual double staining. Two serial sections stained for PHH3 and CK5, respectively, must be used in this APP.