Macrophage migration Inhibitory Factor (MIF) is a dominant cytokine that acts through CD74 to promote cell proliferation, migration and survival pathways in both immune and epithelial cell types. Its binding to CD74 initiates survival pathways and cell proliferation. It is known as a pleiotropic proinflammatory protein for which the effects include the promotion of cytokine expression and inhibition of apoptosis.
The “10131 – MIF, Melanoma, TME” APP detects nuclei and classifies them as either negative, 1+, 2+ or 3+ based on the MIF staining expression present in each nucleus’ vicinity.